Saturday, March 12, 2011
What are the chances of a person with this disease passing the disease to their offspring?
As said in the in the genotype post, in order for a male to receive the disease, the trait has come from the mom. It's impossible for the just father to pass down the trait to his son. Now he can pass it to his daughter. If a mother is carrier of the disease, meaning she is affected on one chromosome, and the father is normal, it's a 50% chance that the their son will inherit the disease. Their daughter has a 50% chance of carrying the trait, but not actually having it. Now if the dad has the disease and the mom is a carrier, it's a 100% the the daughter will inherit the trait; 50% that she'll be a carrier and 50% acquire the disease. As for the son, he, again, has a 50% chance of having the disease. If both parents have full blown Muscular Dystrophy (their both affected, not carriers), then it's a 100% chance that both the boy and girl will have the disease.
Subscribe to:
Post Comments (Atom)
My mother was one of the rare cases of female duchennes. She had three children one boy and two girls, luckily we do not have the disease.I am female with two boys, both healthy, my sister has three girls. We were told in the early 80s that it was a recessive gene and needed both partners to be carriers, we now know this is incorrect. we are wondering if there is any literature on the possible risk of our children passing it on to our grandchildren given my mother was a full blown Duchenne patient?
ReplyDelete